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Publications since 2000

Chowdari KV, Bamne M, Wood J, Talkowski ME, Mirnics K, Levitt P, Lewis DA, Nimgaonkar VL (2008): Linkage disequilibrium patterns and functional analysis of RGS4 polymorphisms in relation to schizophrenia. Schizophr Bull 34:118-26.

Garbett K, Ebert P, Mitchell A, Lintas C, Manzi B, Mirnics K, Persico AM (2008): Immune transcriptome alterations in the temporal cortex of subjects with autism. Neurobiol Dis: In press.

Garbett K, Gal-Chis R, Gaszner G, Lewis DA, Mirnics K (2008): Transcriptome alterations in the frontal cortex of subjects with schizophrenia who committed suicide. Neuropsychopharmacologica Hungarica, 10 (1): 9-14.

Hashimoto T, Arion D, Unger T, Maldonado-Aviles JG, Morris HM, Volk DW, Mirnics K, Lewis DA (2008): Alterations in GABA-related transcriptome in the dorsolateral prefrontal cortex of subjects with schizophrenia. Mol Psychiatry 13:147-61.

Hashimoto T, Bazmi HH, Mirnics K, Wu Q, Sampson AR, Lewis DA (2008): Conserved regional patterns of GABA-related transcript expression in the neocortex of subjects with schizophrenia. Am J Psychiatry 165:479-89.

Krystal JH, Carter CS, Geschwind D, Manji HK, March JS, Nestler EJ, Zubieta JK, Charney DS, Goldman D, Gur RE, Lieberman JA, Roy-Byrne P, Rubinow DR, Anderson SA, Barondes S, Berman KF, Blair J, Braff DL, Brown ES, Calabrese JR, Carlezon WA, Jr., Cook EH, Jr., Davidson RJ, Davis M, Desimone R, Drevets WC, Duman RS, Essock SM, Faraone SV, Freedman R, Friston KJ, Gelernter J, Geller B, Gill M, Gould E, Grace AA, Grillon C, Gueorguieva R, Hariri AR, Innis RB, Jones EG, Kleinman JE, Koob GF, Krystal AD, Leibenluft E, Levinson DF, Levitt PR, Lewis DA, Liberzon I, Lipska BK, Marder SR, Markou A, Mason GF, McDougle CJ, McEwen BS, McMahon FJ, Meaney MJ, Meltzer HY, Merikangas KR, Meyer-Lindenberg A, Mirnics K, Monteggia LM, Neumeister A, O'Brien CP, Owen MJ, Pine DS, Rapoport JL, Rauch SL, Robbins TW, Rosenbaum JF, Rosenberg DR, Ross CA, Rush AJ, Sackeim HA, Sanacora G, Schatzberg AF, Shaham Y, Siever LJ, Sunderland T, Tecott LH, Thase ME, Todd RD, Weissman MM, Yehuda R, Yoshikawa T, Young EA, McCandless R (2008): It is time to take a stand for medical research and against terrorism targeting medical scientists. Biol Psychiatry 63:725-7.

Lintas C, Sacco R, Garbett K, Mirnics K, Militerni R, Bravaccio C, Curatolo P, Manzi B, Schneider C, Melmed R, Elia M, Pascucci T, Puglisi-Allegra S, Reichelt KL, Persico AM (2008): Involvement of the PRKCB1 gene in autistic disorder: significant genetic association and reduced neocortical gene expression. Mol Psychiatry. In press.

Arion D, Unger T, Lewis DA, Levitt P, Mirnics K (2007): Molecular evidence for increased expression of genes related to immune and chaperone function in the prefrontal cortex in schizophrenia. Biol Psychiatry 62:711-21.

Arion D, Unger T, Lewis DA, Mirnics K (2007): Molecular markers distinguishing supragranular and infragranular layers in the human prefrontal cortex. Eur J Neurosci 25:1843-54.

Campbell DB, D'Oronzio R, Garbett K, Ebert PJ, Mirnics K, Levitt P, Persico AM (2007): Disruption of cerebral cortex MET signaling in autism spectrum disorder. Ann Neurol 62:243-50.

Chowdari KV, Northup A, Pless L, Wood J, Joo YH, Mirnics K, Lewis DA, Levitt PR, Bacanu SA, Nimgaonkar VL (2007): DNA pooling: a comprehensive, multi-stage association analysis of ACSL6 and SIRT5 polymorphisms in schizophrenia. Genes Brain Behav 6:229-39.

Dutta R, McDonough J, Chang A, Swamy L, Siu A, Kidd GJ, Rudick R, Mirnics K, Trapp BD (2007): Activation of the ciliary neurotrophic factor (CNTF) signalling pathway in cortical neurons of multiple sclerosis patients. Brain 130:2566-76.

Hidvegi T, Mirnics K, Hale P, Ewing M, Beckett C, Perlmutter DH (2007): Regulator of G Signaling 16 is a marker for the distinct endoplasmic reticulum stress state associated with aggregated mutant alpha1-antitrypsin Z in the classical form of alpha1-antitrypsin deficiency. J Biol Chem 282:27769-80.

Sabatini MJ, Ebert P, Lewis DA, Levitt P, Cameron JL, Mirnics K (2007): Amygdala gene expression correlates of social behavior in monkeys experiencing maternal separation. J Neurosci 27:3295-304.

Smith SE, Li J, Garbett K, Mirnics K, Patterson PH (2007): Maternal immune activation alters fetal brain development through interleukin-6. J Neurosci 27:10695-702.

Arion D, Sabatini M, Unger T, Pastor J, Alonso-Nanclares L, Ballesteros-Yanez I, Garcia Sola R, Munoz A, Mirnics K, DeFelipe J (2006): Correlation of transcriptome profile with electrical activity in temporal lobe epilepsy. Neurobiol Dis 22:374-87.

Dutta R, McDonough J, Yin X, Peterson J, Chang A, Torres T, Gudz T, Macklin WB, Lewis DA, Fox RJ, Rudick R, Mirnics K, Trapp BD (2006): Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients. Ann Neurol 59:478-89.

Ginsberg SD, Mirnics K (2006): Functional genomic methodologies. Prog Brain Res 158:15-40.

Glorioso C, Sabatini M, Unger T, Hashimoto T, Monteggia LM, Lewis DA, Mirnics K (2006): Specificity and timing of neocortical transcriptome changes in response to BDNF gene ablation during embryogenesis or adulthood. Mol Psychiatry 11:633-48.

Hollingshead D, Korade Z, Lewis DA, Levitt P, Mirnics K (2006): DNA self-polymers as microarray probes improve assay sensitivity. J Neurosci Methods 151:216-23.

Koerber HR, Mirnics K, Lawson JJ (2006): Synaptic plasticity in the adult spinal dorsal horn: the appearance of new functional connections following peripheral nerve regeneration. Exp Neurol 200:468-79.

Levitt P, Ebert P, Mirnics K, Nimgaonkar VL, Lewis DA (2006): Making the case for a candidate vulnerability gene in schizophrenia: Convergent evidence for regulator of G-protein signaling 4 (RGS4). Biol Psychiatry 60:534-7.

Lewis DA, Mirnics K (2006): Transcriptome alterations in schizophrenia: disturbing the functional architecture of the dorsolateral prefrontal cortex. Prog Brain Res 158:141-52.

Mirnics K (2006): Microarrays in brain research: Data quality and limitations revisited. Current Genomics 7:11-19.

Mirnics K, Levitt P, Lewis DA (2006): Critical appraisal of DNA microarrays in psychiatric genomics. Biol Psychiatry 60:163-76.

Talkowski ME, Seltman H, Bassett AS, Brzustowicz LM, Chen X, Chowdari KV, Collier DA, Cordeiro Q, Corvin AP, Deshpande SN, Egan MF, Gill M, Kendler KS, Kirov G, Heston LL, Levitt P, Lewis DA, Li T, Mirnics K, Morris DW, Norton N, O'Donovan MC, Owen MJ, Richard C, Semwal P, Sobell JL, St Clair D, Straub RE, Thelma BK, Vallada H, Weinberger DR, Williams NM, Wood J, Zhang F, Devlin B, Nimgaonkar VL (2006): Evaluation of a susceptibility gene for schizophrenia: genotype based meta-analysis of RGS4 polymorphisms from thirteen independent samples. Biol Psychiatry 60:152-62.

Hollingshead D, Lewis DA, Mirnics K (2005): Platform influence on DNA microarray data in postmortem brain research. Neurobiol Dis 18:649-55.

Lazarov O, Robinson J, Tang YP, Hairston IS, Korade-Mirnics Z, Lee VM, Hersh LB, Sapolsky RM, Mirnics K, Sisodia SS (2005): Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice. Cell 120:701-13.

Lewis DA, Levitt P, Mirnics K (2005): Gene expression changes in schizophrenia: How do they arise? What do they mean? Clin Neurosci Res 5:15-21.

Lewis DA, Mirnics K (2005): Genes Dysregulated in Schizophrenia and Schizophrenia Treatment Methods. USA: University of Pittsburgh. Patent application 60/736,593.

Middleton FA, Peng L, Lewis DA, Levitt P, Mirnics K (2005): Altered expression of 14-3-3 genes in the prefrontal cortex of subjects with schizophrenia. Neuropsychopharmacology 30:974-83.

Mirnics K, Korade Z, Arion D, Lazarov O, Unger T, Macioce M, Sabatini M, Terrano D, Douglass KC, Schor NF, Sisodia SS (2005): Presenilin-1-dependent transcriptome changes. J Neurosci 25:1571-8.

Mirnics ZK, Yan C, Portugal C, Kim TW, Saragovi HU, Sisodia SS, Mirnics K, Schor NF (2005): P75 neurotrophin receptor regulates expression of neural cell adhesion molecule 1. Neurobiol Dis 20:969-85.

Unger T, Korade Z, Lazarov O, Terrano D, Schor NF, Sisodia SS, Mirnics K (2005): Transcriptome differences between the frontal cortex and hippocampus of wild-type and humanized presenilin-1 transgenic mice. Am J Geriatr Psychiatry 13:1041-51.

Unger T, Korade Z, Lazarov O, Terrano D, Sisodia SS, Mirnics K (2005): True and false discovery in DNA microarray experiments: transcriptome changes in the hippocampus of presenilin 1 mutant mice. Methods 37:261-73.

Lewis DA, Mirnics K, Levitt P (2004): Transcriptomes in Schizophrenia: Assessing Altered Gene Expression with Microarrays. In Keshavan MS, Kennedy JL, Murray RM (eds), Neurodevelopment and Schizophrenia. Cambridge, UK: Cambridge University Press, pp 210-223.

Mirnics K, Levitt P, Lewis DA (2004): DNA microarray analysis of postmortem brain tissue. Int Rev Neurobiol 60:153-81.

Mirnics K, Pevsner J (2004): Progress in the use of microarray technology to study the neurobiology of disease. Nat Neurosci 7:434-9.

Mirnics ZK, Caudell E, Gao Y, Kuwahara K, Sakaguchi N, Kurosaki T, Burnside J, Mirnics K, Corey SJ (2004): Microarray analysis of Lyn-deficient B cells reveals germinal center-associated nuclear protein and other genes associated with the lymphoid germinal center. J Immunol 172:4133-41.

Pongrac JL, Middleton FA, Peng L, Lewis DA, Levitt P, Mirnics K (2004): Heat shock protein 12A shows reduced expression in the prefrontal cortex of subjects with schizophrenia. Biol Psychiatry 56:943-50.

Hashimoto T, Volk DW, Eggan SM, Mirnics K, Pierri JN, Sun Z, Sampson AR, Lewis DA (2003): Gene expression deficits in a subclass of GABA neurons in the prefrontal cortex of subjects with schizophrenia. J Neurosci 23:6315-26.

Levitt P, Chowdari KV, Nimgaonkar VL, Mirnics K (2003): Methods and systems for facilitating the diagnosis and treatment of schizophrenia. USA: Vanderbilt University. Patent application 20030113721.

Mirnics K (2003): Schizophrenia as a disease of synapse: Gene microarray studies. In Levitt P, Lewis DA, DeFelipe J (eds), Vol 149. Madrid, Spain: Instituto Juan March de Estudios e Investigaciones, pp 36-37.

Mirnics K (2003): Analysis of Mental Disorders Using DNA Microarrays. In Mallet J (ed), Neuroscience at the Post-genomic Era. Paris: IPSEN Foundation, pp 25-42.

Mirnics ZK, Mirnics K, Terrano D, Lewis DA, Sisodia SS, Schor NF (2003): DNA microarray profiling of developing PS1-deficient mouse brain reveals complex and coregulated expression changes. Mol Psychiatry 8:863-78.

Chowdari KV, Mirnics K, Semwal P, Wood J, Lawrence E, Bhatia T, Deshpande SN, B KT, Ferrell RE, Middleton FA, Devlin B, Levitt P, Lewis DA, Nimgaonkar VL (2002): Association and linkage analyses of RGS4 polymorphisms in schizophrenia. Hum Mol Genet 11:1373-80.

Middleton FA, Mirnics K, Pierri JN, Lewis DA, Levitt P (2002): Gene expression profiling reveals alterations of specific metabolic pathways in schizophrenia. J Neurosci 22:2718-29.

Mirnics K (2002): Microarrays in brain research: Data quality and limitations. Current Genomics 3:13-19.

Pongrac J, Middleton FA, Lewis DA, Levitt P, Mirnics K (2002): Gene expression profiling with DNA microarrays: advancing our understanding of psychiatric disorders. Neurochem Res 27:1049-63.

Mirnics K (2001): Gene Expression Microarrays in Brain Research: It is all about design! In Geschwind DH (ed), DNA Microarray Workshop Syllabus. Rockville, MD: Society for Neuroscience, pp 56-67.

Mirnics K (2001): Microarrays in brain research: the good, the bad and the ugly. Nat Rev Neurosci 2:444-7.

Mirnics K, Lewis DA (2001): Genes and subtypes of schizophrenia. Trends Mol Med 7:281-3.

Mirnics K, Lewis DA, Levitt P (2001): DNA Mircroarray Studies of Human Brain Disorders. In Moldin S, Chin H (eds), Methods in Neurogenetics. Boca Raton: CRC Press, LLC, pp 188-217.

Mirnics K, Middleton FA, Lewis DA, Levitt P (2001): Analysis of complex brain disorders with gene expression microarrays: schizophrenia as a disease of the synapse. Trends Neurosci 24:479-86.

Mirnics K, Middleton FA, Lewis DA, Levitt P (2001): The human genome: gene expression profiling and schizophrenia. Am J Psychiatry 158:1384.

Mirnics K, Middleton FA, Lewis DA, Levitt P (2001): Delineating novel signature patterns of altered gene expression in schizophrenia using gene microarrays. ScientificWorldJournal 1:114-6.

Mirnics K, Middleton FA, Stanwood GD, Lewis DA, Levitt P (2001): Disease-specific changes in regulator of G-protein signaling 4 (RGS4) expression in schizophrenia. Mol Psychiatry 6:293-301.

Mirnics K, Middleton FA, Marquez A, Lewis DA, Levitt P (2000): Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex. Neuron 28:53-67.

 

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Last updated: 05/13/08.